MRI radiomic features are associated with survival in melanoma brain metastases treated with immune checkpoint inhibitors

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—an autopsy study

BACKGROUND Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have been recently approved for treatment of patients with metastatic melanoma and non-small cell lung cancer (NSCLC). Despite important clinical benefits, these therapies are associated with a diverse spectrum of immune-related adverse events (irAEs)...

متن کامل

Survival of melanoma patients with brain metastases treated with ipilimumab and stereotactic radiosurgery

UNLABELLED Historically, melanoma with brain metastases has a poor prognosis. In this retrospective medical record review, we report the outcome of patients with stage IV melanoma with brain metastases treated with ipilimumab and brain stereotactic radiosurgery (SRS). All patients with metastatic melanoma treated with ipilimumab from June 2010 to September 2012 were identified and stratified by...

متن کامل

Changing Landscape of Radiotherapy for Melanoma Brain Metastases, in Light of Newer Targeted Agents and Immune Checkpoint Inhibitors.

The standard approach to a patient with a solitary brain metastasis from melanoma has been surgical removal followed by radiation. This approach allows for pathologic diagnosis andmolecular characterization or, for a large symptomatic lesion, the best opportunity for decompression and symptomatic relief. Radiation is currently used for amajority of such patients, in the form of whole-brain radi...

متن کامل

Seroconversion of Hbsag in Melanoma Patient with Hepatitis B Treated with Checkpoint Inhibitors: A Case Report

Based on remarkable and sustained antitumor activity, the anti-CTLA-4 antibody ipilimumab, and anti-PD1 antibodies nivolumab and pembrolizumab have been approved for treatment of advanced melanoma. As checkpoint blockade is associated with potentially serious immune-related adverse events, including autoimmune hepatitis, clinical trials evaluating these agents have excluded patients with chroni...

متن کامل

ZOSTERIFORM METASTASES IN A MAN WITH MALIGNANT MELANOMA

Zosteriform metastasis is a rare clinical distribution from spreading neoplasms of every organ to the skin. Tumors most often arise from a n internal o r hematologic malignancy. W e report a 69-year-old man, a known case of malignant melanoma of the left heel. In this case, multiple red-brown metastatic nodules appeared four months after diagnosis. Distribution of metastatic lesions resemb...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Neuro-Oncology

سال: 2019

ISSN: 1522-8517,1523-5866

DOI: 10.1093/neuonc/noz141